Scientific Discussion
Assistant Professor Dr. Suad Ghazi Jaafar, from the Department of Medical and Molecular Techniques at the Biotechnology Research Center, Al-Nahrain University, participated in the discussion of a master’s thesis at the College of Science, University of Kirkuk. The thesis, titled “Evaluation of the Gene Expression of CD47 and SIRP-α in Diabetic Patients in Kirkuk City,” was presented by the student Thabit Ibrahim Ahmed Al-Dulaimi under the supervision of Assistant Professor Dr. Shelan Khairallah Jabbar.
The study aimed to evaluate the role of gene expression of CD47 and SIRP-α in patients with type 1 and type 2 diabetes and their impact on disease progression. The objectives included estimating the levels of CD47 and SIRP-α in patients and comparing them with healthy individuals, analyzing their gene expression using the qRT-PCR technique, measuring lipid profile levels, blood sugar, and HbA1c, and analyzing changes in protein levels for both genes.
The results revealed a positive correlation between the diabetic group and the SIRP-α protein level, with a higher rate of SIRP-α observed in type 1 diabetes patients compared to type 2 and the control group. The study also demonstrated that the gene expression levels of CD47 have a significant relationship with the progression of diabetes. Additionally, it showed that the gene expression of SIRP-α was higher in healthy individuals compared to diabetic patients.
These findings indicate changes in gene and protein expression associated with disease mechanisms and highlight the importance of these genes in diabetes. This provides a basis for improving diagnostic and therapeutic strategies in the future
